http://localhost:8080/xmlui/handle/123456789/54 2026-01-20T11:34:18Z 2026-01-20T11:34:18Z REG.NO: IH0222002 http://localhost:8080/xmlui/handle/123456789/1903 2025-09-24T07:12:13Z 2025-01-01T00:00:00Z

Title: Immunoprofiling of natural killer cells In normal individuals, tobacco chewers and Patients with oral squamous cell Carcinoma -a flow cytometry study Authors: REG.NO: IH0222002 Abstract: Background- Smokeless tobacco poses a significant global health risk by suppressing the immune system and promoting cancer development, especially oral squamous cell carcinoma (OSCC). NK cells, key components of innate immunity, play a important role in early immunity and tumor surveillance. Tobacco toxins and nicotine impair NK cell function, aiding tumor immune evasion. Immunoprofiling, particularly via flow cytometry, helps assess these immune alterations. This study aimed to evaluate peripheral NK cell immunoprofiles in healthy individuals, tobacco chewers, and OSCC patients to understand immune changes linked to tobacco exposure and cancer.

2025-01-01T00:00:00Z REG.NO: IH0222001 http://localhost:8080/xmlui/handle/123456789/1902 2025-09-24T07:11:14Z 2025-01-01T00:00:00Z

Title: Evaluation of metric & non-metric dental features in ethnic groups of assamese population for forensic profiling: a cross-sectional study Authors: REG.NO: IH0222001 Abstract: Background: Human identification is based on scientific principles, mainly involving dental records, fingerprints, estimation of age, postmortem reports, differentiation by blood groups, and DNA comparisons. Sex assessment is one of the prime factors employed to assist with the identification of an individual with morphometric dimension of teeth.74 Nonmetric dental traits also play crucial role in ethnic classifications of a population that helps in forensic racial identification purposes.8 Aim: Evaluation and Comparison of metric & non-metric dental features amongst four major ethnic groups of Assam for Forensic Profiling.

2025-01-01T00:00:00Z REG.NO.IH0220004 http://localhost:8080/xmlui/handle/123456789/1483 2023-07-25T07:24:41Z 2023-07-25T00:00:00Z

Title: Evaluation of immunoexpression Of cdk14 in normal oral mucosa, Oral epithelial dysplasia and oral Squamous cell carcinoma Authors: REG.NO.IH0220004 Abstract: INTRODUCTION: Oral Squamous Cell Carcinoma (OSCC) constitutes the most prevalent oral cavity cancer. It exhibits an elevated level of local aggressiveness, invasion and involvement of lymphatics, as well as a significant mortality rate. OSCC is mostly preceded by the appearance of precursor lesions with varying degrees of malignant transformation potential. OSCC development and progression are regulated by a variety of molecular mechanisms and pathways. CDK14 belongs to the cyclin- dependent kinase (CDK) menage, which is involved in cancer tumorigenesis. It is found expressed in different types of tumours, including ovarian cancer, hepatocellular carcinoma (HCC), gastric carcinoma, breast cancer, and oesophageal squamous cell carcinoma (ESCC). However, its expression and role in normal oral mucosa (OM), Oral epithelial dysplasia (OED), and OSCC unknown. As a result, the study was directed to examine the expression of CDK14 in normal oral mucosa, OED, and OSCC.

2023-07-25T00:00:00Z REG NO.IH0220003 http://localhost:8080/xmlui/handle/123456789/1482 2023-07-25T07:21:50Z 2023-07-25T00:00:00Z

Title: Expression of fibroblast activation Protein-alpha in oral squamous cell Carcinoma & its association with Lymph node metastasis- an immunohistochemical Study Authors: REG NO.IH0220003 Abstract: Introduction: Oral carcinomas arises as a result of multiple molecular events. This can be either due to exposure to carcinogens present in the environment or genetic predisposition. Once the malignancy is set, histologically several structural alterations take place, both at cellular and tissue level. The tumor microenvironment plays a major role in survival and promotion of cancer cells. Interactions amongst these cellular and structural constituents of the microenvironment confers invasive capabilities to cancer cells and mediate their dissemination to far off locations via complex signalling cascades. Cancer associated fibroblasts/CAF constitutes the most common connective tissue cell in the given TME. It mediates promotion to growth and metastasis of tumor cells by secreting cytokines, growth factors, chemokines, mediating ECM remodelling along-with disruption of inflammatory reactions and immune surveillance pathways. Till date there are very few studies in the literature regarding FAP-a expression in OSCC and its association to histological parameters. Hence, our study aimed at evaluating an association between Expression of Fibroblast Activation Protein-Alpha in OSCC & Lymph Node Metastasis (LNM) and also other prognostic histological parameters.

2023-07-25T00:00:00Z