http://localhost:8080/xmlui/handle/123456789/1048 2026-01-19T17:37:18Z http://localhost:8080/xmlui/handle/123456789/2023 Title: Quality Assesment Profiles of Selected Marketed Classical Ayurvedic Preparations by Chromatographic Techniques Authors: Miss Amruta Ravi Balekundri Abstract: ABSTRACT This study presents a comprehensive investigation into churna formulations, employing a rigorous and systematic approach to evaluate their quality and composition. Through multifaceted analyses, including determination of foreign matter, powder microscopy, physicochemical characterization, microbial studies, physical powder characterization, organoleptic assessment, macroscopic studies, fluorescence studies, qualitative and quantitative phytochemical investigations and HPTLC analysis, a nuanced understanding of the formulations is achieved. Results indicate consistently low levels of foreign matter, highlighting meticulous quality control. Microscopic examination unveils distinct characteristics aiding in identification. Physicochemical parameters offer insights into solubility and acidity/alkalinity. Microbial studies ensure compliance with safety standards. Physical powder characterization reveals favorable flow properties. Organoleptic characterization indicates standardized sensory profiles. Macroscopic studies facilitate raw material identification. Fluorescence studies depict material behavior under different conditions. Qualitative phytochemical investigations enhance understanding of chemical composition, while quantitative assays provide analytical insight into key parameters. HPTLC analyses showcase method reliability, sensitivity, and eco-friendliness, with quantification of Piperine contributing to formulation characterization. The eco-friendliness evaluation emphasizes sustainable analytical practices. In conclusion, this study employs a holistic methodology to comprehensively characterize churna formulations, offering valuable insights into their quality, composition, and potential therapeutic efficacy, thus contributing to the advancement of herbal medicine 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/2022 Title: Role Of Macro And Micronutrients In The Management Of Glycogen Storage Disease Manifestations – A Preclinical Study Authors: Mr.Santosh Basavaraj Patil Abstract: ABSTRACT Background Glycogen storage disease type 1 (GSD type 1) is an inherited metabolic disease resulted due to the impaired glucose-6-phosphatase enzyme complex, which is important in glycogen metabolism. The enzyme complex glucose-6-phosphatase (G6Pase), is encoded by G6PC1 gene, and the glucose-6 phosphate translocase or transporter subunit (G6PT), which is encoded by the SLC37A4 gene. The major manifestations of GSD type 1 are hypoglycemia, excessive glycogen accumulation, hepatomegaly, hyperuricemia, hyperlactatemia. This study investigates the induction and management of GSD I symptoms. It is known that metformin may affect the levels of lactic acid, and that chlorogenic acid (CGA), which is prevalent in green coffee and present in various kinds of fruits, inhibits the enzyme glucose-6-phosphatase complex and micronutrients which inhibits the glycogenesis process were employed for the management of hepatic glycogen accumulation, which is responsible for further other manifestations as mentioned above. Objectives: To establish a chemically induced GSD model, which could facilitate to investigate the most common GSD type 1 manifestations and to investigate the influence of dietary regimen consisting of macronutrients and micronutrients in experimentally induced GSD manifestations. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/2021 Title: Evaluation of essential oils For anti-asthmatic activity by Using animal models Authors: Ms.Shilpa Sharma Abstract: ABSTRACT Background: The therapeutic management of asthma relies heavily on bronchodilator and anti-inflammatory inhalers, which, although effective, often require long-term use and can be associated with various side effects. Seeking alternatives to mitigate or potentially eliminate these side effects has led to exploration of alternative and complementary medicinal systems, including the use of medicinal plants in folklore therapy. While many plants have been traditionally used for treating various ailments, their diverse ethno-pharmacological applications lack conclusive scientific evidence for safe and rational use. Nevertheless, the phytochemical composition of plants continues to provide a rich source of novel chemical entities for drug discovery. Essential oils derived from plants have long been employed in traditional medicine for respiratory infections and are now being recognized in mainstream medicine for their therapeutic potential in conditions such as bronchitis, sinusitis, and asthma. These essential oils demonstrate antiinflammatory effects on the respiratory tract, offering promising avenues for both acute and chronic respiratory conditions. Objective: The present investigation aimed to evaluate the activity of the essential oil of Mentha arvensis L. Origanum vulgare L, Moringa oleifera, Zanthoxylum armatum, Zingiber officinale, Angelica glauca, Alpinia galangan, Curcuma domestica, Cinnamomum camphora and Cinnamomum aromaticum on exogenously induced bronchoconstriction in experimental animals. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/2020 Title: Formulation And Evaluation Of Vaginal Drug Delivery System Of Tenofovir: An Experimental Study Authors: Dr.Dhruti Avlani Abstract: ABSTRACT Background: Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) pose significant worldwide challenges. Low oral bioavailability of antiretroviral s ( AntiRV), hinders their effectiveness in reaching infection sites and increasing the risk of relapse. Preventative measures like topical vaginal pre exposure prophylaxis (PrEP) are crucial in reducing HIV transmission for HIV negative individuals to lower their virus contraction risk during intercourse. Objectives: The first part of the project aimed to design and develop novel PrEP sispersible vaginal tablets ( DT composed of tenofovir disoproxil fumarate TDF loaded bio adhesive chitosan microparticles (T CM). The second part focused on formulating pessaries with TDF loaded bio adhesive sodium alginate ( S Alg ) microspheres (T AM) for intra vaginal administration to address the shortcomings associated with conventional oral dosage forms. 2024-01-01T00:00:00Z