http://localhost:8080/xmlui/handle/123456789/60 2026-01-18T17:14:30Z http://localhost:8080/xmlui/handle/123456789/2048 Title: Study of effect of intranasal Dexmedetomidine on stress response to Pneumoperitoneum in laparoscopic surgeries: a One year double blinded hospital based Randomised clinical trial Authors: REG NO.:BA0122020 Abstract: Background: Insufflation in laparoscopic surgeries may cause sympathetic stimulation, which can cause tachycardia and hypertension. Dexmedetomidine, a potent alpha-2 adrenoceptor agonist is gaining popularity to abolish this pressor response. This study explores the effect of intranasally used dexmedetomidine on stress response to pneumoperitoneum. Aims and Objectives: To determine the effect of intranasal dexmedetomidine on stress response to pneumoperitoneum in laparoscopic surgeries and to determine the side effects of the study drug if any. 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/2047 Title: Comparison of two different doses of dexmedetomidine In attenuation of sevoflurane associated emergence Agitation in paediatric patients, posted for lower Abdominal surgeries –a hospital based, randomized Controlled trial. Authors: REG NO.:BA0122019 Abstract: BACKGROUND: Emergence Agitation (EA) is a very common immediate postoperative complication encountered in paediatric population undergoing anaesthesia with Sevoflurane. Owing to its low blood solubility and rapid recovery, Sevoflurane is the best inhalational agent for use in paediatric age group. But its disadvantage of causing agitation is distressing to the anaesthesiologists. Dexmedetomidine is found to reduce the incidence of EA. Fewer studies have been done comparing the effects of particularly two doses (0.3 mcg/kg and 0.5 mcg/kg) of Dexmedetomidine. Hence this study was designed to compare the effectiveness of these two doses in reducing EA in children. AIM: To assess the effectiveness of two different doses of Dexmedetomidine 0.3 mcg/kg IV and 0.5 mcg/kg IV, given intraoperatively in reducing postop EA along with the changes in hemodynamic parameters after drug administration. 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/2046 Title: Comparison of budesonide spray And water based gel as an Endotracheal tube cuff lubricant On incidence of postoperative sore Throat: randomized control study Authors: REG NO.:BA0122018 Abstract: Background: Postoperative sore throat (POST) is a common complication following endotracheal intubation under general anesthesia. Various pharmacological interventions, including corticosteroids and lubricants, have been explored to minimize its incidence. This randomized controlled study compares the effectiveness of budesonide spray and water-based gel (K-Y jelly) as endotracheal tube (ETT) cuff lubricants in reducing POST. Methods: A total of 178 patients, aged 18–60 years, undergoing elective surgery under general anesthesia were randomly assigned to two groups. Group B received 200 mcg of budesonide spray on the ETT cuff, while Group K had the cuff lubricated with 2 ml of K-Y jelly. The primary outcome was the incidence and severity of POST, assessed at multiple postoperative time points (immediately, 10 min, 1 hr, 6 hrs, and 24 hrs). Secondary outcomes included the incidence of postoperative cough and hoarseness. 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/2045 Title: To compare leak volume with and Without the application of positive endexpiratory Pressure with i-gel based General anaesthesia in pediatric patients- a one year randomised control trial Authors: REG NO.:BA0122017 Abstract: Background: General anesthesia (GA) is an essential component of pediatric surgical procedures, ensuring unconsciousness, analgesia, and muscle relaxation. The use of supraglottic airway devices, such as the I-gel, has gained attention due to their ability to maintain airway patency with minimal complications. Positive end-expiratory pressure (PEEP) is widely used in adult patients to improve oxygenation and reduce airway collapse, but its benefits in pediatric patients undergoing I-gel-based GA remain unclear. This study aims to compare the effects of applying PEEP on airway leak volume and leak fraction in pediatric patients. Aims and Objectives: This study aims to compare leak volume, leak fraction, end-tidal CO₂, and peak inspiratory pressure in pediatric patients undergoing I-gel-based general anesthesia with and without 5 cm H₂O of PEEP to assess its impact on ventilation efficiency and airway leaks. 2025-01-01T00:00:00Z