http://localhost:8080/xmlui/handle/123456789/75 2026-01-20T08:26:55Z http://localhost:8080/xmlui/handle/123456789/1876 Title: The Effect Of Rivaroxaban And Dabigatran On Glycemic Parameters And Lipid Profile In High Fat Diet And Low Dose Streptozotocin Induced Diabetes Mellitus In Male Wistar Rats Authors: REG.N0: BO0121004 Abstract: Introduction The current experimental study aimed to evaluate the effect of Rivaroxaban and Dabigatran on glycemic parameters in a High-fat diet and low dose Streptozotocin-induced Diabetes Mellitus in male Wistar rats. In addition, the effect on the Lipid profile and inflammatory markers were also assessed. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1875 Title: Effect Of Cilnidipine on Depression Paradigm in Male Swiss Mice-An Experimental Study Authors: REG.N0: BO0121003 Abstract: Introduction Depression is a commonly occurring ailment that frequently coexists with cardiovascular problems, impacting approximately 16-23% of individuals. Emerging genetic, ex vivo, and clinical trial evidence suggest that Calcium channel blockers (CCB) have a positive effect on mood and cognitive performance. The hypothesis posits that calcium channel blockers (CCB) alter the release of central neurotransmitters, particularly noradrenaline (NA) and 5-hydroxytryptamine (5-HT) contribute to the occurrence of depression. Nevertheless, the therapy now accessible has limitations in terms of effectiveness and the accompanying negative consequences. Study Objectives: 1. To evaluate the effects of Cilnidipine on depression paradigm in Male Swiss Mice using the Forced Swim Test, Tail Suspension Test and Locomotor Activity Test. 2. To compare the effects of Cilnidipine and Fluoxetine on depression paradigm in Male Swiss Mice using the Forced Swim Test, Tail Suspension Test and Locomotor Activity Test. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1874 Title: Effect Of Withania Somnifera On Selected Gene Expression In Brain Tissue Of Male Wistar Rats Subjected To Chronic Stress Induced Depression Authors: REG.N0: BO0121002 Abstract: Introduction and Objective :- The present study was designed to evaluate the effect of Withania somnifera (WS) alone and in combination with Fluoxetine on gene expression of Neuritin, NARP & BDNF Exon – III gene in hippocampus of male Wistar rats using chronic unpredictable mild stress (CUMS) as a model of depression. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1873 Title: Investigation of Cardioprotective Potential of Remogliflozin in preventing Streptozotocin induced Diabetic Cardiomyopathy in Male Wistar Rats Authors: REG.N0: BO0121001 Abstract: Introduction and objective - One of the cardiac problems that diabetes patients face is Diabetic Cardiomyopathy (DCM), which can lead to heart failure and an increase in morbidity and death. The two main pathogenic characteristics of diabetic hearts that contribute to the development of DCM are inflammation and oxidative stress. Because of its anti-oxidant and anti-inflammatory qualities, remogliflozin, an SGLT 2 inhibitor, has been demonstrated to lessen inflammation and oxidative stress. The purpose of this study was to look at how Remogliflozin protects diabetic hearts and assess via the corresponding changes in blood marker and histological characteristics. 2024-01-01T00:00:00Z