http://localhost:8080/xmlui/handle/123456789/52 Thu, 08 Jan 2026 11:13:58 GMT 2026-01-08T11:13:58Z http://localhost:8080/xmlui/handle/123456789/1968 Title: Combination of melatonin with Hyaluronic acid for socket Preservation following extraction Of posterior teeth – A randomized controlled trial Authors: REG.NO:IF0222006 Abstract: Background and Methodology: Tooth extraction often leads to significant alveolar bone loss, particularly within the first year due to natural remodeling processes. Up to 50% of buccolingual width can be lost, complicating prosthetic rehabilitation. Hyaluronic acid (HA) and melatonin have emerged as promising biomaterials for socket preservation, enhancing soft tissue healing and minimizing complications like dry socket. HA promotes angiogenesis and osteoblast activity, while melatonin reduces oxidative stress and inflammation, supporting osteogenesis. Earlier fewer studies suggested their synergistic potential for improving clinical outcomes, but randomized controlled trials are needed to evaluate their efficacy in posterior extraction sockets. The primary objective was to evaluate the anti-inflammatory effect of Melatonin with Hyaluronic acid on post-operative pain through Visual Analog Scale (VAS). Secondary objectives were to evaluate patient’s satisfaction towards postoperative pain control, postoperative supplemental analgesic rescue use (time and dose), wound healing potential and osteogenic potential of the combination. This was a split mouth single-blind randomized controlled trial carried out in the department of Oral and maxillofacial surgery, KLE VK Dental College, Belagavi from December 2023 to October 2024. 25 patients requiring bilateral extraction of either maxillary or mandibular premolars and molars were included. The study samples were divided into two extraction sites – wherein for the study site, post-extraction an Absorbable Gelatin sponge (AGS) soaked in Mixture of Melatonin and Hyaluronic acid was viii placed in the socket followed by routine closure. In control site post-extraction, the sockets were left for spontaneous healing. The follow up was done at 3rd day, 5th day, 7th day and 4 months post operatively. Wed, 01 Jan 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1968 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1967 Title: Intra-alveolar use of ozone oil after Transalveolar extractions for pain Control and wound healing –A randomized controlled trial Authors: REG.NO:IF0222005 Abstract: BACKGROUND: Transalveolar extraction is a critical surgical approach for removing teeth that cannot be extracted using conventional forceps or elevators, particularly in cases of severe impaction, root ankylosis, or complex root morphology, it carries significant postoperative challenges, including pain, swelling, and restricted mouth opening (trismus), which may prolong recovery and patient discomfort. There has been growing interest in adjunctive therapies to enhance postoperative outcomes, with ozone therapy emerging as a promising intervention. Ozone oil, when used in extraction sockets, helps regulate inflammation, stimulate blood vessel formation (angiogenesis), and encourage fibroblast growth, all of which are essential for proper wound healing. Its antibacterial effects also lower the chances of post-surgical infections, aiding in faster recovery. The primary objective was to evaluate the effect of ozone oil on postoperative pain. Secondary objective was to evaluate the effect of ozone oil on postoperative swelling, trismus, and wound healing and to evaluate and compare the postoperative frequency of analgesic usage. Wed, 01 Jan 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1967 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1966 Title: Evaluation of clinical outcomes of cold saline, hydrocortisone and normal saline as an irrigating solution during surgical removal of impacted mandibular third molars -a randomized control trial Authors: REG.NO:IF0222004 Abstract: Introduction: Mandibular third molars are the most commonly impacted teeth and their surgical removal is one of the most common surgical procedures performed by the Oral and Maxillofacial Surgeon. Most of the available literature supports the use of Cold saline to reduce the post-operative sequelae of orthopaedic surgeries & implant surgery , namely pain, swelling, but there is not much evidence found in literature to determine if it is effective when used topically as an intraoperative irrigating solution during surgical removal of lower third molar. The present study is deliberated to assess the effect of irrigation with three different Irrigants, namely Cold saline(2-8o), Hydrocortisone and Normal Saline in post operative outcomes and complications like pain, swelling and trismus after surgical extraction of mandibular third molars Wed, 01 Jan 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1966 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1965 Title: To assess the bone regeneration in extraction sockets using simvastatin in comparison to rosuvastatin: a randomized control trial Authors: REG.NO:IF0222003 Abstract: STATEMENT OF PROBLEM Tooth extraction invariably leads to alveolar ridge resorption, compromising masticatory function, esthetics, and future implant placement. Traditional socket-preservation techniques—autografts, allografts, xenografts, and exogenous growth factors—are limited by donor-site morbidity, immunologic risks, infection potential, and inconsistent outcomes. Statins, beyond their lipid-lowering action via HMG-CoA reductase inhibition, have been shown to upregulate bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF), promoting osteoblast differentiation and angiogenesis. These properties position locally applied statins as promising pharmacologic graft substitutes for preserving post-extraction sockets. PURPOSE A randomized clinical trial was designed to assess and compare the efficacy of locally applied Simvastatin versus Rosuvastatin in enhancing alveolar bone regeneration following tooth extraction Wed, 01 Jan 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1965 2025-01-01T00:00:00Z