http://localhost:8080/xmlui/handle/123456789/79 Wed, 21 Jan 2026 00:19:03 GMT 2026-01-21T00:19:03Z http://localhost:8080/xmlui/handle/123456789/1886 Title: Association of BAL Cartridge Based Nucleic Acid Amplification Test Grading on the Basis of cycle of threshold value with time to culture positivity Authors: REG NO: BR0121005 Abstract: Background and Objectives: Tuberculosis (TB) continues to be a major global health issue, with India bearing a significant burden of the disease. The emergence of drug-resistant TB and the need for rapid and accurate diagnostic methods underscore the importance of this study. This research aims to investigate the association between cycle threshold (CT) values from Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) and the time to culture positivity (TTCP) in patients with pulmonary and extrapulmonary tuberculosis. Specifically, the study focuses on bronchoalveolar lavage (BAL) samples, which have not been extensively researched in this context Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1886 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1885 Title: The efficacy of 1% versus 2% lignocaine Solution administered by “working Channel” method for topical anesthesia in Flexible bronchoscopy without Administration of concurrent lignocaine Nebulization – one year rct Authors: REG NO:BR0121004 Abstract: INTRODUCTION Flexible bronchoscopy is essential in respiratory medicine field for the diagnosis and management of respiratory conditions by direct airway visualization, enabling sample collection and many therapeutic interventions. Effective topical anesthesia is crucial for patient comfort and procedural safety as it is a day care procedure. Lignocaine, commonly used due to its efficacy and safety, is administered via nebulization, "spray-as-you-go," or direct application through the bronchoscope's working channel. While nebulization may cause uneven anesthetic distribution, the working channel method offers controlled application. This study compares the efficacy and safety of 1% versus 2% lignocaine solution administered via the working channel without nebulization, aiming to determine if a lower concentration can provide effective anesthesia with fewer risks and safer hemodynamic outcomes. OBJECTIVES · The primary objective of this study is to compare the hemodynamic effects of 1% versus 2% lignocaine used as a topical anesthetic during flexible bronchoscopy. · Secondary objectives include evaluating patient comfort using the Visual Analog Scale (VAS), assessing operator satisfaction through cough severity score and cough count, determining the necessity for additional anesthesia methods, calculating the cumulative lignocaine doses, and identifying any procedural side effects of lignocaine. viii · Additionally, the study aims to assess the impact of the topical anesthetic on bacterial cultures obtained during the procedure Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1885 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1884 Title: Role of serum fibrinogen levels in determining the severity and prognosis of acute exacerbation of copd patients – an observational study Authors: REG NO:BR0121003 Abstract: BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by declining respiratory function, exercise capacity, and health status. COPD exacerbations are a significant cause of morbidity and mortality, particularly in India, where frequent hospitalizations due to acute exacerbations (AECOPD) are reported. This study aims to assess the role of serum fibrinogen levels in determining the severity and prognosis of AECOPD patients, as fibrinogen is a promising biomarker for inflammation and COPD severity Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1884 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1883 Title: Clinical effectiveness of triple drug therapy combination containing laba, lama and ics in non-smoking copd patients- a prospective study over a period of 12 weeks Authors: REG NO: BR0121002 Abstract: INTRODUCTION Chronic obstructive pulmonary disease (COPD) is a significant global health issue, characterized by persistent respiratory symptoms, including dyspnoea, cough, sputum production, and recurrent lower respiratory tract infections. These symptoms degrade the quality of life and precipitate acute exacerbations leading to hospitalizations. A unique subgroup, nonsmoker-COPD (NS-COPD), is defined by the absence of tobacco smoke exposure but includes other environmental or internal illnesses contributing to COPD. This study aims to evaluate the clinical effectiveness of triple therapy (LABA, LAMA, ICS) in managing NS-COPD. OBJECTIVE To evaluate the clinical effectiveness of triple drug therapy combination containing LABA, LAMA and ICS in non-smoking COPD patients Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/1883 2024-01-01T00:00:00Z