Cubosome based Nanoformulation of resveratrol and piperine For targeting melanoma

Abstract

Abstract Melanoma is one of the most aggressive type of skin cancer, with high incidence rate and mortality, throughout the world. Despite of noteworthy development in melanoma treatment, the destructive nature of the disease makes it difficult for clinicians to manage the condition. Hence, there is need remains to achieve improved therapeutic activity and overall survival time using herbal constituents, which can offer improved efficacy over existing chemotherapy, in melanoma therapy. Resveratrol (RV) and piperine (PI) are the model drugs of choice for their potential antimelanoma activity. However, their clinical application is limited due to their poor pharmacokinetic properties.

Objectives The current research work aims to investigate the effect of Cubosomal nanoformulation of RV and PI against Melanoma.Hence the objectives of thestudy are:

1. To formulate, evaluate and optimize RV and PI loaded cubosomal nanoformulation. 2. To study anticancer activity of optimized cubosomal nanoformulation against Melanoma.