Evaluation of the chemotherapeutic potential of resveratrol entrapped nanoliposomes for targeting hepatocellular carcinoma

Abstract

Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. The destructive nature of the disease makes it difficult for clinicians to manage the condition. Hence, there is an urgent need to find new alternatives for HCC, as the role of conventional cytotoxic drugs has reached a plateau to control HCC associated mortality. Antioxidant compounds of plant origin with potential anti-tumor effect have been recognized as alternate modes in cancer treatment and chemoprevention. Resveratrol (RSV) is a model natural nonflavonoid drug known for its anti-cancer activity. However, its clinical application is limited due to its poor bioavailability.

Objectives The current research work aims to formulate, optimize, and characterize RSV loaded cationic liposomes (RCL) for specific delivery in HCC. Hence the objectives of the study are: 1. Formulation and optimization of RCL using 3 2. Characterization of prepared RCL drug delivery system. xx 2 factorial design. 3. In-vitro cytotoxicity studies, cytocompatibility and cellular uptake studies of RSV and RCL. 4. In-vivo pharmacokinetic profiling and anticancer pharmacodynamic study of RSV and RCL in NDEA induced HCC bearing rats.