Molecular mechanism and herb drug interaction of hydro-alcoholic extract of Terminalia arjuna bark and its ayurvedic formulations in metabolic syndrome

Abstract

ABSTRACT : Disorders like obesity, diabetes mellitus (DM), dyslipidemia and hypertension are grouped under metabolic syndrome (MS) with complex etiology, multifactorial pathogenesis and require prophylactic and therapeutic interventions. In our traditional knowledge and Indian civilizations, different herbal medicines have been advocated for DM. It is notable that Terminalia arjuna (TA) utilized in dyslipidemia, hyperglycemia, malignancy, high blood pressure and hypercholesterolemia. Arjunarishta (AA) and Arjun Ghritah (AG) are hydroalcoholic and ghee based formulation of TA respectively. These ayurvedic medicines were used to treat a lipid and cardiovascular disorders. Herbs are taken with the belief that they are helpful and safe in reducing side and adverse effects of prescription drugs. This leads to increased incidences of herb-drug interactions (HDIs). As adequate gaps present in the literature about the molecular mechanism, and HDIs, more research study in this direction is required to cover the essential issues. Objectives: The objective of the study was to assess the molecular mechanism and HDI of hydro alcoholic TA extract (TAHA) of bark and its ayurvedic formulations in MS