Preparation And Characterization Of Tamoxifen Loaded Transdermal Drug Delivery System For Estrogen Receptor Positive Breast Cancer

Abstract

Background and Objective: Conventional administration of drugs to target the cancer cell has the disadvantages of providing relatively low concentrations of the drug at the site of action. Hence, Tamoxifen citrate (TC) loaded matrix and solid lipid nanoparticle gel reservoir systems can deliver high therapeutic effective concentration of drug either in the site or site of tumor excision. In the present study, hydrophilic and lipophilic polymers are selected to develop transdermal patches. The objective of the present research work is to develop transdermal patches of tamoxifen citrate for estrogen receptor positive breast cancer using matrix and transdermal solid lipid nanoparticle reservoir systems.