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http://localhost:8080/xmlui/handle/123456789/1140| Title: | Solubility Enhancement, System design for transbuccal delivery, in-vitro characterization and in-vivo evaluation of Lovastatin |
| Authors: | Mrs.Bhuvaneshwari R.SharannavarM |
| Keywords: | Lovastatin, PEG 4000, PVPK30, Solid dispersion, HPMCK4M, HPMC E5LV, chitosan, Ex-vivo bioadhesion, ex-vivo permeation, bioavailability. |
| Issue Date: | 2020 |
| Publisher: | KLE Academy of Higher Education and Research, Belagavi |
| Abstract: | Abstract: Background: Lovastatin (LVS); HMG CoA inhibitor, is a drug of choice for hyperlipidemia. Its clinical efficacy is limited due to its low aqueous solubility, incomplete absorption, short-half life, first pass metabolism, low bioavailability, and adverse effects etc. Objective: The objective of the present study was to improve the solubility of Lovastatin and develop mucoadhesive film of solid dispersions for buccal delivery to enhance bioavailability. |
| URI: | http://localhost:8080/xmlui/handle/123456789/1140 |
| Appears in Collections: | Faculty of Pharmacy |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Bhuvaneshwari R.SharannavarM_2020_Faculty of Pharmacy.pdf | 14.45 MB | Adobe PDF | View/Open |
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