Assessment of the effect of advanced Platelet rich fibrin (a-prf) on Proliferation, migration and attachment Of human periodontal ligament fibroblasts – an in-vitro study.

Abstract

ABSTRACT: Backgroud: Platelet concentrates have been proposed as a therapeutic tool to enhance and promote cellular and molecular mechanisms during wound healing and periodontal regeneration. Recently, the use of Advanced platelet rich fibrin (A-PRF) has shown to be more potent than the standard PRF in terms release of growth factors and the architecture of their fibrin network. The architecture of A-PRF matrix with even distribution of cells and growth factors can enhance the activity of different cell lines over a definite period of time and provide cell availability for periodontal tissue repair and regeneration.