To compare the effects of oral melatonin versus oral Pregabalin for attenuation of hemodynamic response to Laryngoscopy and endotracheal intubation in adult Patients undergoing general anesthesia. A one year Hospital based randomized clinical trial.

Abstract

Background: Endotracheal intubation is one of the standard procedures to secure an airway. Following laryngoscopy, there is a hemodynamic response because of the noxious stimulus which results in reflex sympathetic stimulation. This results in haemodynamic changes. These changes undesirable and has detrimental effects on patients with diseases like coronary artery diseases, vascular anomaly & aneurysm. To attenuate hemodynamic changes various drugs & techniques are used. Recently some studies show evidence of using agents like oral Melatonin (MT) and oral Pregabalin are effective in attenuating haemodynamic response. The present prospective randomized study is comparing efficacy of both the drugs. Methods: - After obtaining approval from ethical committee,60 patients were recruited who were belonging to ASA Grade 1&2, aged between 18-60years and randomized into 2 groups. These patients received two tablets of either oral melatonin(6mg) group A or oral pregabalin (150mg) group B 120minutes prior to laryngoscopy and intubation. The haemodynamic changes were noted at baseline, at induction & post-intubation at 1min,3min,5min,10min respectively and tabulated.