Effectiveness of ramosetron for prevention of shivering In patients undergoing infraumbilical surgeries under Spinal anaesthesia – one year hospital based, double Blinded randomized clinical trial.

Abstract

Background and Aim: Perioperative shivering (POS) is a commonly observed cumbersome problem in patients undergoing surgeries under spinal anaesthesia (SA). Various non-pharmacological and pharmacological approaches have been tried and tested to prevent and control shivering. Shivering has tremendous deleterious effects on the body metabolism. Numerous studies supported the anti-shivering property of 5-HT3 receptor (5-HT3R) antagonists, even though not a single study has shown substantial results. This study intends to determine the efficacy of ramosetron (a 5-HT3 receptor antagonist) 0.3mg intravenously (i.v) when compared with 0.9% normal saline(NS) to prevent post spinal shivering (PSS) during planned infraumbilical surgeries.