Comparative Evaluatoin of Antifungal Efficacy and Potency of Soft-Liners Incorported with Powder Extracts of Lawsonia Inermis and Withania Somnifera on the growth of Candida Albicans-An vitro study.

Abstract

STATEMENT OF PROBLEM: Denture induced candidiasis is mainly associated with infection caused by Candida species. Application of topical antifungal agents has become a challenge for geriatric denture- wearers due to their reduced motor activity and loss of memory. Topical and systematic antifungal therapy requires patient compliance. Thus, result or the outcome cannot be determined. Denture soft liners are used in conditioning the exploited mucosa due to improper fitting of the denture. Antifungal medicaments are integrated into the soft liner thereby helping the patients in the treatment of Oral Candidiasis. Continuous use of synthetic antifungal agents has resulted in harmful effects on the patients like liver and kidney toxicity and also have disadvantages like drug resistance. Excessive use of these synthetic drugs has increased the emergence of multi-drug resistance (MDR) strains of micro-organisms. Therefore, the use of natural and herbal drugs have come into the role with less adverse effects. The natural powder extract of Lawsonia inermis and Withania Somnifera have been proven to be effective against Candida albicans. AIM:

To evaluate and compare the antifungal efficacy and potency of denture soft- liners incorporated with leaves powder extract of Lawsonia inermis linn. (lythraceae) and root powder extract of Withania somnifera dunal. (solanaceae) on the growth of candida albicans.