Development And Optimization Of Apigenin Nanoparticle For Targeting Breast Cancer

Abstract

Background Breast cancer (BC) the most frequent type benign tumor in women, and it's amongst the most common type of tumor deaths worldwide, comprising 26-288 of their cancer cases and roughly 19% of breast cancer-related fatalities in underdeveloped nations, and it is the second largest cause of death (45%) next to cervical cancer. BC expanded by 10% in the female population during the last two decades. Clinicians find it challenging to cure the disease because of its destructive character. As a result, novel approaches for BC are urgently needed, as the usefulness of existing cytotoxic medications in controlling BC-related mortality has approached a level. Antioxidant molecules derived from plants that have various cancer treatment and chemoprevention techniques have been found that have anti-tumor characteristics. Apigenin (API) is a component of natural flavonoid medication with cancer-fighting effects. However, due to its poor pharmacokinetics properties, their clinical applicability is limited. Objectives The present research project aims to investigate the effect of Apigenin loaded stealth liposomes in BC. Hence the objectives of the study are: 1. To formulate, evaluate and optimize Apigenin loaded stealth liposomes. 2. To study anticancer activity of optimized Stealth liposomes against Breast Cancer (BC) by in vitro and in vivo methods