Formulation and evaluation of gastroretentive Dosage form of calcium

Abstract

Background: Calcium is mainly absorbed from the stomach and upper gastro intestinal tract and due to site specificity and pH dependency leading to lower bioavailability and it quickly passes from the absorption site. In such scenario, gastro retentive drug delivery system could be potential alternative to overcome the limitations associated with currently available dosage forms. Objective: To develop and evaluate gastroretentive systems as sigle unit bilayer tablets and insitu gelling raft forming solution of calcium carbonate (CC) with objective to prolong the gastric residence time (GRT) and thereby increasing the bioavailability.