Synthesis Of Levamisole Derivatives For Anti Cancer Activity

Abstract

Cancer is responsible for millions of death every year. The drugs used to treat cancer bear severe side-effects. Hence, there is always a need for effective and safer molecules against it. It can be achieved either by screening the NCE or repurposing the existing one. The bioisosteric replacement on a synthetically versatile scaffold often gives the molecule with desired biological properties. In-silico analysis of existing drugs is also in use to find new anticancer moiety. Cell line based study, heterocyclic synthesis and CADD play vital role inthe process. Objectives: Objectives of the work is to design, synthesize and screen 2,6-substituted-imidazo[2,1-b] [1,3,4]thiadiazoles as levamisole derivativewith desired cytotoxic property and convert them to a potential lead against cancer.