Effect of Ketogenic Diet Intermittent Fasting and High Carbohydrate Diet on Chronic Inflammation in Male Wistar Rats

Abstract

Background It has been long recognized that diet is crucial in causation and management of chronic Non Communicable Diseases (NCDs). Chronic inflammation of mild to moderate intensity contributes to pathogenesis of several NCDs. Literature reveals that a diet rich in carbohydrate is a crucial risk factor in causation of NCDs. Hence a rational approach to diminish the risk of developing NCDs would be to reduce carbohydrate consumption by ketogenic diet (KD) or intermittent fasting (IF). Hence, the current study was undertaken. Objectives: To determine the effects of ketogenic diet, intermittent fasting, high carbohydrate diet and a combination of intermittent fasting with ketogenic diet on chronic inflammation (induced by Complete Freund’s adjuvant) - (CFA) and oxidative stress parameters in male Wistar rats.