Evaluation of diagnostic significance of Trophoblast cell surface antigen-2 expression in Thyroid neoplasms- a study in tertiary care Centre of belagavi.

Abstract

BACKGROUND: Thyroid cancer is the commonest endocrine malignancy and incidence continues to increase worldwide from past few decases.(12,13)Although differentiation of benign and malignant lesions can be made with hematoxylin & eosin (H&E) stained histopathological slides, challenges are being faced when there is absence of characteristic nuclear features of papillary thyroid carcinoma(PTC), encapsulated follicular lesions with a suspicious capsular & vascular invasion, neoplasm of thyroid follicular cells with follicular pattern and nuclear features of PTC.(12,21,22) Hence immunohistochemistry(IHC) markers are helpful in definitive diagnosis of morphologically overlapping cases. Trophoblast cell surface antigen 2 is a novel IHC marker and stated to be more sensitive and specific in diagnosing PTC. OBJECTIVE: Primary objective:- To evaluate the diagnostic significance of TROP-2 expression in thyroid neoplasms. Secondary objective:- To correlate clinical diagnosis with histopathological findings of thyroid lesions.