Study Of Immunohistochemical Expression Of Akt (Protein Kinase B) In Prostatic Adenocarcinoma -A Descriptive Study At Tertiary Care Hospital, Belagavi

Abstract

BACKGROUND: In men, prostatic cancer is the third most common malignant tumour and the second leading cause of carcinoma death. P-Akt is a phosphorylated protein kinase B, a central signalling molecule which participates in the genesis and progression of malignancies. Increased Akt expression has been associated with high Gleason’s scores. Prostate specific antigen (PSA) is a biochemical tumour marker in prostatic adenocarcinoma and helps in diagnosing cancer and cancer recurrence. The Gleason’s score is used to evaluate the prognosis of prostatic cancer. OBJECTIVES: To study immunohistochemical expression of p-Akt and the correlation of histological grading with PSA in prostate adenocarcinoma.