To study cd64 expression on neutrophils as a novel biomarker in early diagnosis of sepsis in pediatric age group 0 - 18 year

Abstract

Background & Objective: The most prevalent cause of neonatal death is sepsis. In India, the incidence of neonatal sepsis was 30 per 1000 live births according to the National Neonatal Perinatal Database (NNPD) from 2002 to 2003. Despite the fact that blood culture is the gold standard for diagnosing sepsis, culture findings would only be available 48–72 hours later with a sensitivity of 25 – 55%. Earlier majority of studies done were in neonates only and so there is paucity of data of sepsis in paediatric age group. Hence there is a need to study other biomarkers like CD64 and CRP,that can detect sepsis early with good sensitivity to start treatment without waiting for blood culture report and good specificity so that multidrug resistance would be prevented in treating non-infected patients with unnecessary antibiotics in paediatric age group