Prevalence of carbapenemase producing klebsiella pneumoniae isolated from various clinical samples- a one year cross sectional study

Abstract

Study Background: Multi-drug-resistant organisms causing community-acquired and healthcare-associated infections are increasing at a dangerous rate globally. Among them, the Enterobacteriaceae family, primarily Klebsiella pneumoniae, are most commonly responsible for deadly infections. Commonly seen resistance patterns are due to the presence of Extended-spectrum β-Lactamase (ESBL) or acquired cephalosporins (AmpC)-producing organisms that are resistant to all β-Lactams except carbapenems. But recently, it has been observed that there has been an increase in the prevalence of carbapenem-resistant Klebsiella species resulting in treatment failure. Therefore, it is the need of the hour to implement an appropriate, cost-effective, and straightforward phenotypic method for the detection of Carbapenemase-producing Klebsiella pneumoniae for further prevention and spread of CP-KPN. Objectives: 1. To detect the prevalence of Carbapenemase production in Klebsiella pneumoniae in various clinical samples by using the modified Carbapenemase Inactivation Method. 2. Compare antibiotic sensitivity pattern and Carbapenemase production in hospital-acquired and community-acquired infections among Klebsiella pneumoniae isolates.