Use of narrow band imaging in endoscopic evaluation of angiogenesis in laryngeal lesions- a one year observational study in dr. Prabhakar kore hospital

Abstract

BACKGROUND - NBI is a Biologic Endoscopy which works by evaluating biological behaviour of targeted lesions and allows a clearer distinction between malignant lesions, their precursors and also non malignant lesions. Lesions invisible on WLI are also sometimes highlighted and seen. NBI evaluates neo angiogenesis of a lesion thereby minimizing unnecessary need for biopsies and histopathological evaluation. Angiogenesis is process of forming new blood vessels. For growth of tumour cells and their metastatic growth, development of vascular network is important since cancer cells have high metabolic need and require good availability of nutrients and oxygen. (8) Therefore neoangiogenesis is key in allowing growth and spread of tumours. It's a sign of how far a tumour has progressed, and in H&N SCC, its role has been investigated. New vessels formed through tumour angiogenesis arise from other vessels and exhibit irregular patterns and branching. Characteristic changes are variations in appearance of vessels in superficial mucosa seen as “Intraepithelial Papillary Capillary Loop” (IPCL). These are evaluated with help of NBI in order to look for angiogenesis. OBJECTIVE- To evaluate role of narrow band imaging in diagnosis of various laryngeal lesions