Efficacy of varying time intervals between Fentanyl and propofol administration on Propofol requirement for inducton of Anaesthesia a one year randomized control Trial

Abstract

ABSTRACT | ] ackground: Administration of Fentanyl prior 10 propofol for induction ; anaesthesia should result in a significant decrease in the amount of propofol need . ic ility, aid in a steady for induction and its side effects and maintain hemodynamic stability, induction of anacsthesia. This study looked at how different times between the injection of fentanyl and propofol affected the amount of the drug needed to induce anaesthesia. Methods: Following ethical committee permission, 102 patients with ASA Grades 1 and 2, between the ages of 18 and 60, were enrolled and randomly assigned to one of three groups. Fentanyl was administered to these individuals immediately, 3 minutes, and 5 minutes before the onset of anaesthesia. Hemodynamic changes related to the medications and time periods were recorded and tabulated, as well as the overall amount of propofol needed for induction. Results: Compared to the group that received propofol immediately after fentanyl administration, the total amount of propofol needed to induce anaesthesia was significantly reduced with a 3 minute time interval variation, and hemodynamics were tolerated better with a 5 minute group. Conclusion: The current study contributes to the conclusion that premedicating with fentany for three and five minutes decreases the total amount of propofol needed for inducing anaesthesia. However, more study is needed.