Attenuation Of Hemodynamic Response To Laryngoscopy And Endotracheal Intubation: A Comparison Between Intranasal Dexmedetomidine And Intravenous Preservative Free Lignocaine -- A One Year Hospital Based Double Blinded Randomised Clinical Trial

Abstract

Direct laryngoscopy and endotracheal intubation following induction of general anesthesia is associated with hero«dynamic variations due to reflex sympathetic discharge. Transient hypertension and tachycardia are probably of no consequence in healthy individuals, hut either or both may be hazardous tu those with hypertension, myaeandial insufficieney and cerebrovascular diseases. A variety of drugs have been used to control this bemodynamie response. such as lignocaine. magnesium sulphate vasodilators. beta blackers, calcium channel blockers. all'a 2 agonists and opioids. OBJECTIVES: Comparison of intranasal dexmedetomidine with intravenous preservative free lignaeaine to attenuate stress response to laryngoscopy and endotracheal intubation with respect to hemadynamie variables like Mean arterial pressure, Systolic blood pressure. Diastolic blood pressure & Heart rate and to see the side effects if any.