Evaluation of immunoexpression Of cdk14 in normal oral mucosa, Oral epithelial dysplasia and oral Squamous cell carcinoma

Abstract

INTRODUCTION: Oral Squamous Cell Carcinoma (OSCC) constitutes the most prevalent oral cavity cancer. It exhibits an elevated level of local aggressiveness, invasion and involvement of lymphatics, as well as a significant mortality rate. OSCC is mostly preceded by the appearance of precursor lesions with varying degrees of malignant transformation potential. OSCC development and progression are regulated by a variety of molecular mechanisms and pathways. CDK14 belongs to the cyclin- dependent kinase (CDK) menage, which is involved in cancer tumorigenesis. It is found expressed in different types of tumours, including ovarian cancer, hepatocellular carcinoma (HCC), gastric carcinoma, breast cancer, and oesophageal squamous cell carcinoma (ESCC). However, its expression and role in normal oral mucosa (OM), Oral epithelial dysplasia (OED), and OSCC unknown. As a result, the study was directed to examine the expression of CDK14 in normal oral mucosa, OED, and OSCC.