Evaluation of Cynodon dactylon L and Sida rhombifolia L on cognitive dysfunction in rats

Abstract

Background Most common form of dementia is Alzheimer's disease, is an incurable disease affecting elder population. For the management of dementia symptoms, symptomatic medications are administered; however, persistent use of these medications is linked with undesirable effects. Traditional neurotherapeutics are in the pipeline of modern therapy to halt the progression of AD. Medicinal plants Cynodon dactylon L. and Sida rhombifolia L. have been reported with pharmacological activities viz, hemorrhages, dysentery, hyperdipsia anti-inflammatory, wound healing, hepatoprotective. Traditionally, selected plants are claimed as brain and heart tonic, however preclinically both the plants have limited reports on the management of dementia hence, current study explored to evaluate the efficacy in treatment of dementia in rats. Aims & Objectives: Evaluation of effect of “hydro-ethanolic extract of Cynodon dactylon L. and Sida rhombifolia L. against cognitive dysfunction integrated by in-silico methods and experimental models (in-vitro, in-vivo).