Pharmacological Evaluation of Cocoa on Efficacy and Toxicity of Doxorubicin in Murine Ascites and Solid Tumor

Mrs.Priyanka P. Patil, D01217016

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DC Field	Value	Language
dc.contributor.author	Mrs.Priyanka P. Patil, D01217016	-
dc.date.accessioned	2023-09-25T06:03:55Z	-
dc.date.available	2023-09-25T06:03:55Z	-
dc.date.issued	2023	-
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/1501	-
dc.description.abstract	Background: Doxorubicin (DOX) is an extensively utilised chemotherapy drug, oxidative stress caused by it can damage the heart, liver, and kidneys. Theobroma cacao L. (cocoa) is reported to possess protective efficacy against several chemical- induced organ damages and also anticancer activity. The present study aimed to evaluate the effect of cocoa extract (COE) on doxorubicin-induced organ damage in mice with Ehrlich ascites carcinoma (EAC) by employing in silico, in vitro, and in vivo studies. Objective: 1. To assess protective activity of cocoa against Doxorubicin induced organ toxicities (Heart, Liver and Kidney) in a mouse bearing ascites & solid tumor 2. To assess Cytotoxic activity of Doxorubicin in combination with cocoa in a mouse bearing ascites & solid tumor	en_US
dc.language.iso	en_US	en_US
dc.publisher	KLE Academy of Higher Education and Research, Belagavi	en_US
dc.subject	Anticancer; Cardiotoxicity; Cytotoxicity; Cocoa; Doxorubicin; Ehrlich ascites carcinoma; Hepatotoxicity; Molecular docking; Molecular dynamics; Network Pharmacology; Nephrotoxicity; organ toxicity; Theobroma cacao Linn;	en_US
dc.title	Pharmacological Evaluation of Cocoa on Efficacy and Toxicity of Doxorubicin in Murine Ascites and Solid Tumor	en_US
dc.type	Phd Thesis	en_US
Appears in Collections:	Faculty of Pharmacy

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