ROLE OF MRI IN PEDIATRIC DEMYELINATING DISORDERS - ONE YEAR HOSPITAL BASED CROSS SECTIONAL STUDY

Abstract

BACKGROUND: The acquired demyelinating disorder (ADD) is characterized by the destruction or damage of normally myelinated structures of the central nervous system (CNS) which are immunologically mediated. Acquired demyelinating disorders encountered during childhood include acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), Clinically isolated syndrome (CIS) and the more recently discovered anti-myelin oligodendrocyte glycoprotein (anti-MOG)–associated encephalomyelitis. Radiologists play a major role in the diagnosis and differentiation these diseases. Recent discovery of some key MRI imaging features which can be explained by the pathophysiological basis of these different entities. It helps in identifying magnetic resonance imaging predictors of a particular demyelinating diagnosis in the pediatric population which can have broad implications on treatment of the disease. The aim of this study is to determine the clinical profile and imaging features of the pediatric acquired demyelinating disorders of the central nervous system.