SERUM FERRITIN LEVELS IN NEWBORNS AT 3 MONTHS OF LIFE AFTER INTACT UMBILICAL CORD MILKING VERSUS DELAYED CORD CLAMPING” – RANDOMIZED CONTROLLED TRI

Abstract

INTRODUCTION: The major public health concern worldwide, especially in developing countries like India is Anemia in infancy, which later results in impairment of brain development and maturation, growth retardation, poor cognitive, motor and social- emotional development. According to WHO in 2021 prevalence of anemia was seen in more than half of the population in the Southeast Asia region, and about 50% of cases were due to iron deficiency (WHO; 2021). From the analysis of the National family health survey (NFHS) -5 data, a study found that the anemia prevalence among children in India is 75.2% at 6-8 months, 78.7% at 9-11 months. The timing of umbilical cord clamping has a profound effect on blood volume and in turn on the total iron content of newborn. We can minimize perinatal iron deficiency by either of the two placental transfusion interventions which we currently followed like delaying umbilical cord clamping [Passive transfusion] or by Intact umbilical cord milking (UCM) which results in rapid flow of blood from the placenta to baby [Rapid transfusion]. OBJECTIVES: • PRIMARY: To evaluate the levels of Serum ferritin in late preterm and term newborns after intact umbilical cord milking versus delayed cord clamping at 3rd month of life. xiv • SECONDARY: A) Impact of delayed cord clamping versus intact umbilical cord milking on hemoglobin (Hb), hematocrit at 3-5 days of life and at the 3rd month of life. B) APGAR score at one and five minutes. C) Total serum bilirubin, direct serum bilirubin at 3-5days of life and development of jaundice requiring phototherapy or exchange transfuse ion in both groups, development of polycythemia (hematocrit>65%) and hemodynamic parameters like Capillary refilling time, Respiratory rate, Heart rate and Oxygen saturation at 3-5 days