COMPARISON OF EFFICACY AND SAFETY OF ORAL IBUPROFEN VERSUS INTRAVENOUS PARACETAMOL IN THE CLOSURE OF PATENT DUCTUS ARTERIOSUS IN PRETERM NEONATES, A ONE YEAR RANDOMISED CONTROL TRIAL

Abstract

INTRODUCTION Ductus arteriosus (DA) is a communication between thepulmonary artery and the aorta.Generally ,the functional closure of the ductus arteriosus occurs in the first 72 hours of life and anatomical closure occurs within first 2-3 weeks of life.It is one of the most common problems in the preterm infants and accounts for about 10% ofcongenital heart lesions. A small PDA remains asymptomatic and is diagnosed by a murmur whereas , a large DA may result in heart failure. Clinical criteria for hsPDA are Tachycardia, bounding pulse with wide pulse pressure, hyperdynamic precordium with continuous murmur on auscultation, hepatomegaly, and the failure of respiratory distress syndrome to improve within 2–7 days. AIMS AND OBJECTIVE PRIMARY OBJECTIVE: To compare the efficacy of oral Ibuprofen and IV Paracetamol in the closure of hsPDA in preterm neonates. SECONDARY OBJECTIVE: To determine the safety and adverse effects of both ibuprofen and paracetamol.