Histochemical study of Mucopolysaccharides and microscopic Structure of osteoarthritic menisci Of the human knee joint ====Done

Abstract

Background: Osteoarthritis (OA) is a progressively disabling joint disease caused by a pathological imbalance between degenerative and repair processes, for which there is currently no cure. It is one of leading causes of chronic disability. Patients affected by this disease experience pain and loss of function. OA can be caused by a variety of factors, including diet, injury, stress, and genetic abnormalities. However, the molecular mechanisms driving the disease onset and progression are not fully understood. Knowledge regarding changes of mucopolysaccharides (proteoglycans) in human osteoarthritis meniscus may help in understanding development of meniscal degeneration. Therefore, this study is undertaken to estimate a large number of human OA menisci for study of mucopolysaccharides and microscopical structural changes in osteoarthritic menisci by histochemical analysis of different parts of medial and lateral menisci of both legs. Objectives: 1. To study the histochemistry of mucopolysaccharides in osteoarthritic menisci of a Human knee joint. 2. To study the microscopic structure of menisci in osteoarthritic patients. 3. To compare the age-related changes in histological structure and mucopolysaccharide changes in osteoarthritic menisci.