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http://localhost:8080/xmlui/handle/123456789/1668| Title: | Evaluating anti cholera toxin Activity of pure herbal compounds From traditional medicinal plants |
| Authors: | Mrs.Rajitha Charla |
| Keywords: | Cholera toxin; Cell free culture filtrate; GM1 ELISA; Cytotoxicity; Docking; Molecular dynamics simulation |
| Issue Date: | 2024 |
| Publisher: | KLE Academy of Higher Education and Research, Belagavi |
| Abstract: | Background: Careya arborea, Punica granatum, Psidium guajava, Holarrhena antidysenterica, Aegle marmelos and Piper longum are traditional medicines used to treat diarrheal diseases in India and supported by scientific literature. But their specific activity against Cholera toxin (CT) has not been explored yet. Aim and objectives: The current study aimed to investigate the inhibitory activity of these plants against CT-induced cytotoxicity and enterotoxicity. Polyphenols were selected from plants that showed efficient neutralization activity against CT. The inhibitory activity of selected polyphenols against CTB binding to GM1 receptor was further investigated using computational and experimental approaches. |
| URI: | http://localhost:8080/xmlui/handle/123456789/1668 |
| Appears in Collections: | Faculty of Interdisciplinary Studies |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Mrs. Rajitha Charla.pdf | 5.88 MB | Adobe PDF | View/Open |
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