Formulation characterization and Pharmacological evaluation of chrysin loaded Phytosomes in colorectal cancer in Wistar Rats

Abstract

Background Chrysin is a phytoconstituent belonging to flavonoid category which exhibits various pharmacological activities including anti-cancer. However, the oral bioavailability of chrysin is severely low due to its poor aqueous solubility, extensive first pass metabolism and stability problems. Objectives The main objective of the present study is to formulate and characterize chrysin loaded phytosomes and pharmacologically evaluate its anticancer activity for the treatment of colorectal cancer in Wistar rats.