Evaluation Of Serum Uric Acid Level In Primary Hypertension – A One Year Crosssectional Study

Abstract

Background and objectives It is reported that, there is association between serum uric acid levels (SUA) and hypertension (HTN). This study was aimed to evaluate the relationship between SUA levels and primary HTN. Methods This one year hospital based cross sectional study was conducted from January 2018 to December 2018 in the Department of General Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi. A total of 100 patients with primary hypertension were enrolled. These patients were evaluated for SUA levels and severity of HTN based on 2017 ACC/AHA guidelines. Results Thepresentstudy showedstrong correlationbetween SUA levelwith systolic blood pressure (SBP) and diastolic blood pressure (DBP) inpatientswithprimary HTN.Elevated SUA levels weresignificantlyassociated with body mass index (BMI) andDyslipidemia. Themean SUA levelswere 6.36±2.33mg/dLand raised SUA wasseenin38%.The meanSBP (163.89±9.99 vs 151.4±10.78 mmHg p<0.001)andmeanDBP (95.89±3.83 vs 91.96±5.15 mmHg p<0.001)weresignificantlyhighinhyperuricemic patients. The mean SUA levelsinstage2 HTN (6.38±2.37mg/dL)were highcomparedtostage1 HTN (5.77±0.79mg/dl).Male tofemaleratio was2.12:1.SignificantcorrelationwasseenbetweenBMIand SUA levels (r=0.559;R2=0.313;p<0.001). Significant correlationwasseenbetween SUA level with totalcholesterol (r=0.548;R2=0.299;p<0.001), low density lipoprotein (r=0.467;R2=0.299;p<0.001), high density lipoprotein (r=0.467;R2=0.217;p<0.001) and triglyceride (r=0.446;R2=0.199;p=0.013) levels. Conclusion and interpretation Patients with primary HTN arelikelytopresentwithraised SUA levelsandthereisstrongassociationbetweenelevated SUA levelswithSBP andDBP.Furthermoreelevated SUA levelsaresignificantlyassociatedwithBMIanddyslipidemia. Howeverthehyperuricemia inpatientswithprimaryHTNisindependentofsexandage