Clinical and Dermoscopic Evaluation to study the Effectiveness of Metformin vs Pioglitazone in Acanthosis Nigricans – A Randomized Control Trial

Abstract

ABSTRACT Background and Objectives: Acanthosis Nigricans (AN) is defined by thick, hyperpigmented skin of flexural areas, often indicating underlying systemic conditions like metabolic syndrome. Its prevalence is escalating, notably reaching 6.5% in India. AN severity correlates with insulin resistance, emphasizing the importance of addressing underlying conditions. Dermoscopic examination aids diagnosis by revealing characteristic features. Metformin and pioglitazone are commonly used for insulin resistance in AN, yet comparative efficacy data is lacking. This study evaluates the clinical improvement, metabolic profile, and dermoscopic changes in patients of AN treated with metformin and pioglitazone.