Correlation between mean platelet volume and Severity of sepsis in patients admitted in the Intensive care unit at kle dr.prabhakar kore hospital And medical research centre, belagavi –A one year cross-sectional study

Abstract

BACKGROUND: Sepsis is defined as a life threatening organ dysfunction caused by a dysregulated host response to infection. APACHE – II is a scoring system which is used to classify the severity of sepsis. It is done using patient parameters measured within the first 24 hours after admission to the Intensive Care Unit. A higher score is associated with a more adverse outcome. In an inflammatory process such as sepsis, there is an interplay between the immunological and the haemostatic systems. Platelets while being primarily haemostatic cells, show characteristic changes in morphology in response to inflammatory mediators. These morphological changes can be assessed using the Platelet Indices which are routinely measured by the 7 part CBC analyser, one of which is the Mean Platelet Volume. vii AIM: To establish the correlation between the Mean Platelet Volume and severity of sepsis based on APACHE II score in patients of sepsis admitted to the Intensive Care Unit of KLE’s Dr.Prabhkar Kore Hospital and MRC.