Prevalence Of Secondary Hyperparathyroidism In Patients With Stage 5 Chronic Kidney Disease On Maintenance Hemodialysis’’ – A One Year Hospital Based Cross-Sectional Study

Abstract

BACKGROUND AND OBJECTIVES: Disturbances in mineral metabolism are commonly seen in patients with chronic renal failure. But there are very few studies on their prevalence in Indian dialysis population. Objective of our study was to know the prevalence of secondary hyperparathyroidism in patients with stage 5 chronic kidney disease on maintenance hemodialysis. METHODS: This cross sectional study was done on patients undergoing maintenance hemodialysis. Patients were examined for clinical features of secondary hyperparathyroidism and serum calcium, phosphorus, alkaline phosphatase, 25 hydroxy vitamin D and intact parathyroid hormone levels were measured. RESULTS: 85 patients were included in our study. Various mineral, bone abnormalities were as follows- hypercalcemia (5.88%), hypocalcemia (36.47%), hyperphosphatemia (30.59%), hypophosphatemia (28.24%), hyperparathyroidism (36.48%), hypoparathyroidism (10.59%), deficiency of vitamin D(52.94%) and insufficiency of vitamin D (20%). iPTH levels had positive correlation with phosphorus and alkaline phosphatase levels, negative correlation was significant between iPTH and calcium levels. iPTH levels did not differ significantly in diabetics, compared to non-diabetics and also between patients undergoing 8 and 12 hours of dialysis. INTERPRETATION AND CONCLUSION. Prevalence rate of secondary hyperparathyroidism was 36% in our study and 40% had oversuppresion of iPTH levels. One third of our patients had a risk of adynamic bone disease. URI: