Study of effectiveness of Topical insulin on healing of Diabetic ulcers at tertiary Health care center

Abstract

BACK GROUND Diabetes mellitus presents a significant challenge to global healthcare systems, with diabetic ulcers being a major complication. Despite advances in wound care, these ulcers often resist conventional treatments, leading to prolonged patient suffering and substantial healthcare costs. Recent interest in topical insulin therapy stems from its potential to improve wound healing outcomes by addressing underlying pathophysiological mechanisms disrupted by chronic hyperglycemia. While preclinical studies suggest efficacy, clinical evidence remains limited and inconclusive due to methodological shortcomings. Rigorous, well-designed clinical trials are needed to evaluate the true effectiveness of topical insulin therapy in managing diabetic ulcers and filling current knowledge gaps. OBJECTIVE: To assess the effectiveness of the topical insulin application in diabetic patients and To Compare the effectiveness of topical insulin application versus normal Saline dressings in diabetic patients