Observational study of effect of Co2 pneumoperitoneum on liver Function following laparoscopic Cholecystectomy

Abstract

BACKGROUND:- Laparoscopic surgery has revolutionized modern surgical practices by offering minimally invasive alternatives to traditional open procedures, enhancing patient outcomes and recovery times. Utilizing carbon dioxide (CO2) pneumoperitoneum to create a working space within the abdominal cavity, laparoscopic techniques have become standard for various surgeries including cholecystectomy. Despite its advantages, CO2 insufflation at pressures above 14 mmHg and prolonged operative durations can lead to transient alterations in liver function tests (LFTs), notably elevations in serum liver enzymes such as AST and ALT. These changes, though often clinically insignificant in patients with normal hepatic function, prompt questions regarding their mechanism, clinical relevance, and potential mitigation through modified surgical techniques. This study investigates the prevalence and clinical implications of such enzyme elevations post-laparoscopic cholecystectomy, aiming to contribute to the understanding and management of liver function changes associated with CO2 pneumoperitoneum in surgical settings.