Correlation Of Cumulative Dose And Duration Of Steroid Therapy With Ocular Manifestations In Children With Nephrotic Syndrome - A One-Year Cross Sectional Study

Abstract

Introduction: Nephrotic syndrome (NS) is the most common kidney disease in children aged 2 to 18 years, which presents with massive proteinuria (40mg/m2/hour), hypoalbuminemia (< 2.5 gm/dl), hypercholesterolemia and edema. Corticosteroids and sodium restriction are the mainstay therapy for nephrotic syndrome. The disease has a chronic, relapsing course requiring repeated, prolonged course of steroid therapy. Long term use of corticosteroids is associated with ocular complications like increased risk of cataract formation and development of glaucoma. Objective of the Study:  To study correlation of cumulative dose and duration of steroid therapy with ocular manifestations in children with nephrotic syndrome.  To study the steroid independent ophthalmic findings in children with NS