Effect Of Cilnidipine on Depression Paradigm in Male Swiss Mice-An Experimental Study

Abstract

Introduction Depression is a commonly occurring ailment that frequently coexists with cardiovascular problems, impacting approximately 16-23% of individuals. Emerging genetic, ex vivo, and clinical trial evidence suggest that Calcium channel blockers (CCB) have a positive effect on mood and cognitive performance. The hypothesis posits that calcium channel blockers (CCB) alter the release of central neurotransmitters, particularly noradrenaline (NA) and 5-hydroxytryptamine (5-HT) contribute to the occurrence of depression. Nevertheless, the therapy now accessible has limitations in terms of effectiveness and the accompanying negative consequences. Study Objectives: 1. To evaluate the effects of Cilnidipine on depression paradigm in Male Swiss Mice using the Forced Swim Test, Tail Suspension Test and Locomotor Activity Test. 2. To compare the effects of Cilnidipine and Fluoxetine on depression paradigm in Male Swiss Mice using the Forced Swim Test, Tail Suspension Test and Locomotor Activity Test.