To assess the bone regeneration in extraction sockets using simvastatin in comparison to rosuvastatin: a randomized control trial

Abstract

STATEMENT OF PROBLEM Tooth extraction invariably leads to alveolar ridge resorption, compromising masticatory function, esthetics, and future implant placement. Traditional socket-preservation techniques—autografts, allografts, xenografts, and exogenous growth factors—are limited by donor-site morbidity, immunologic risks, infection potential, and inconsistent outcomes. Statins, beyond their lipid-lowering action via HMG-CoA reductase inhibition, have been shown to upregulate bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF), promoting osteoblast differentiation and angiogenesis. These properties position locally applied statins as promising pharmacologic graft substitutes for preserving post-extraction sockets. PURPOSE A randomized clinical trial was designed to assess and compare the efficacy of locally applied Simvastatin versus Rosuvastatin in enhancing alveolar bone regeneration following tooth extraction