Estimation of salivary matrix metalloproteinases- 8 (mmp-8) and its correlation to periodontal inflamed surface area (pisa) before and after non-surgical periodontal therapy

Abstract

INTRODUCTION Matrix metalloproteinase-8 (MMP-8) is a key enzyme involved in collagen degradation and is considered a promising indicator of periodontal tissue destruction. Given its involvement in periodontal inflammation, MMP-8 holds promise as a biomarker for identifying individuals at risk of developing periodontitis. MMP-8 is detectable in oral fluids such as saliva and gingival crevicular fluid. The available studies used conventional periodontal parameters which inadequately measured the inflammatory burden posed by the periodontal disease. A new tool Periodontal Inflamed Surface Area (PISA) was developed which provides a quantitative measure of inflammation by calculating the surface area of bleeding pocket epithelium using CAL, recession and bleeding on probing. No existing studies have explored the relationship between MMP-8 and PISA levels pre and post non-surgical periodontal therapy. AIM Estimation of salivary MMP-8 and its correlation to PISA before and after non-surgical periodontal therapy