Comparative evaluation of osteoblastic response on titanium discs coated with l-prf (leucocyte platelet rich fibrin) and a-prf+ (advanced platelet rich fibrin plus) - an invitro study.

Abstract

ABSTRACT STATEMENT OF PROBLEM Success of a dental implant relies on its osseointegration process. Ever since osseointegration concept was introduced, there have been number of techniques and materials that have been developed to increase the bone implant contact and decrease the time required for osseointegration. PRF is an autologous fibrin-based (membrane, matrix or scaffold), living biomaterial, derived chairside from centrifugation of blood without any external additives or anti-coagulant, contains growth factor rich platelets , fibrinogen (acting as a supportive matrix), and cells (mostly the leucocytes, and stem cells for their antibacterial, neo-vascularization and regenerative properties), thus making it the most autogenic ideal source for regeneration and healing .The research related to the osteogenic potential of PRF coating on titanium surfaces are at sparse. Hence it becomes necessary to evaluate the effect of PRF and its osteogenic potential for early osseointegration of dental implants. Therefore, this invitro study was undertaken with an intent to evaluate and compare osteoblastic response on titanium discs coated with A-PRF+ (Advanced platelet rich fibrin plus) and L-PRF (Leucocyte platelet rich fibrin) coated titanium discs. AIM: The aim of the present study was to evaluate and compare the osteoblastic response of Advanced platelet-rich fibrin plus (A-PRF+) and Leucocyte platelet rich fibrin (L-PRF) coated titanium discs.