Evaluation of antifungal activity Against candida albicans, water Sorption and solubility of a soft Liner incorporated with root extract Of licorice (glycyrrhiza glabra)-an in vitro study

Abstract

ABSTRACT STATEMENT OF PROBLEM Denture-induced Candidiasis is mainly associated with infection caused by Candida species. The application of topical antifungal agents has become a challenge for geriatric denture wearers due to their reduced motor activity and loss of memory. Topical and systemic antifungal therapy requires patient compliance. Thus, the result or the outcome cannot be determined. Continuous use of synthetic antifungal agents has resulted to have harmful effects on the patient’s liver and kidney and has disadvantages like drug resistance. Excessive use of these synthetic drugs has increased the emergence of multidrugresistant strains of microorganisms. Therefore, the use of natural and herbal drugs has come into picture that have fewer adverse effects. The root extract of Licorice (Glycyrrhiza glabra) has proven to be effective against Candida albicans hence it was incorporated into the soft liner. PURPOSE The aim of the study was to evaluate and compare the antifungal effect, water sorption and solubility of the denture soft liner incorporated with Glycyrrhiza glabra.