Evaluate the efficacy of curry leaves (murraya koenigi) incorporated bio gel Against early peri-implantitis pathogens - an in vitro study

Abstract

ABSTRACT STATEMENT OF PROBLEM The removal of natural teeth due to caries, trauma, or periodontal conditions needs the replacement in terms of restorative procedure such as removable partial dentures, fixed partial dentures or dental implants. Osseo-integrated implants, exhibit significant longevity and success rates ranging from 83.9% to 98%. However, even after successful Osseo-integration implant might lead to failure because of periimplantitis. It is characterized by inflammation and progressive bone loss around implants. Depending on the severity, the management of peri-implantitis is classified as non-surgical and surgical. Non-surgical management consist of manual debridement and use of adjuvant like chlorhexidine gluconate (CHX), to overcome the side-effects of commercially available 1% CHX gel the herbal remedies can be used, because of their antimicromial and non-cytotoxic properties. Curry leaf (Murraya koenigii) has demonstrated antibacterial activity against various pathogens, including those associated with early periimplantitis. In particular, its incorporation into biogels, for their site specific action. The present study aims to formulate and evaluate the antimicrobial activity of Curry leaf (Murraya koenigii) incorporated biogels against early periimplantitis pathogens. By exploring novel formulations that harness the therapeutic potential of herbal extracts in controlled drug delivery systems. PURPOSE To formulate and evaluate the efficacy of Curry leaves (Murraya Koenigii) incorporated bio gel against Staphylococcus aureus and Porphyromonas gingivalis in early peri– implantitis pathogens adhered to Titanium and Zirconia discs.