Comparative evaluation of antibacterial,anti-inflammatory, anti-oxidative efficacy of tissue conditioner incorporated with punica granatum extract in differentconcentrations: an in-vitro study

Abstract

ABSTRACT STATEMENT OF PROBLEM: Obturators are widely used in prosthetic rehabilitation for maxillofacial defects. To lower the danger of contamination and infection, surgical obturators are first positioned after surgery. As healing advances, these are eventually replaced by temporary and permanent prosthesis. Infection, which is frequently caused due to pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa & Proteus mirabilis & Enterobacter spp., can interfere with this process of healing. NSAIDs & corticosteroids are common anti inflammatory drugs, however long term use of these drugs can cause systemic toxicity. Tissue conditioners might exacerbate bacterial colonisation, which jeopardises recovery even more. Tissue conditioners are used for cushioning surgical obturators & protect healing tissues. Herbal remedies with established antibacterial and anti inflammatory qualities have been suggested as an alternative to this issue. Rich in bioactive substances like tannins, flavonoids, & polyphenols, Punica granatum, has strong anti inflammatory, antibacterial, and antioxidant properties. The purpose of this in vitro investigation is to assess the effectiveness of tissue conditioner supplemented with various concentrations of Punica granatum extract. AIM: To evaluate and compare the antimicrobial, anti inflammatory and anti oxidative efficacy of tissue conditioner incorporated with Punica granatum in different concentrations.