Antimicrobial efficacy and osteogenic Potential of triphala and cissus Quadrangularis combination, as aHydrogel coating on implant surface For peri-implantitis and Osseointegration- an in-vitro study

Abstract

ABSTRACT STATEMENT OF PROBLEM Implant dentistry provides essential functions such as normal shape, aesthetics, speech, and health, even in cases of atrophy, disease, or injury to the stomatognathic system. Ti6Al4V titanium alloys are preferred for their mechanical properties and biocompatibility over traditional materials like stainless steel 316L and cobalt-chromium alloys. However, titanium has limitations as an implant material. Such as lack of antimicrobial property, bio inertness which leads to increases the risk of implant failure or loosening. Surface modification also seeks to improve the implant’s antibacterial qualities, corrosion resistance, and bioactivity while maintaining its mechanical qualities and biocompatibility. Although commercially available antimicrobials are used to address early periimplantitis, their release at suboptimal concentrations may lead to bacterial resistance, while high doses can disrupt the oral microflora, cause cell toxicity, and hinder osseointegration. This research study explores traditional natural medicines to achieve predictable results on specific parameters. Triphala Powder (TC), a blend of three fruits—Emblica officinalis, Terminalia bellerica, and Terminalia chebula—is rich in vitamin C, nicotinic acid, and Chebulinic acid, which have antimicrobial and antifungal properties. Incorporating TC into a hydrogel mixture can enhance the implant osteotomy site by decreasing microbial activity. Additionally, Cissus quadrangularis, another herbal remedy, has shown osteogenic potential, which may facilitate bone formation between the bone and implant, improving bone-implant contact and osseointegration. The study aims to assess how well TC and CQ integrate xxv in a hydrogel form to address osseointegration and antimicrobial efficacy, highlighting the potential benefits of these natural remedies in implant dentistry. AIM To Evaluate the efficacy of novel hydrogel containing Triphala and Cissus Quadrangularis extracts, for antimicrobial activity and osteogenic potential at the site of dental implant.